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KMID : 0359720220400020172
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Journal of the Korean Neurological Association
2022 Volume.40 No. 2 p.172 ~ p.175
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Transient Mutism Related to Capecitabine-Induced Acute Toxic Leukoencephalopathy
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Kim Hyung-Ho
Kim Hyun-Ji
Kim Su-Min
Kim Soo-Hyun
Kim Geon-Ha
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Abstract
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Capecitabine, a precursor of 5-fluorouracil (5-FU), is a well-tolerated and safe chemotherapy that has been used to treat breast, pancreatic, and colorectal cancers. Albeit rare, both 5-FU and capecitbine have been reported to be associated with acute central nervous system toxicity, including cerebellar dysfunction, posterior reversible encephalopathy syndrome, and transient leukoencephalopathies. Here we present a case of 32-year-old female, demonstrating transient mutism related to capecitabine induced acute toxic leukoencephalopathy.
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KEYWORD
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Capecitabine, Leukoencephalopathy, Mutism
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